smooth muscle Myosin heavy chain 11 (MYH11) Rabbit Polyclonal Antibody

CAT#: AP05579PU-N

smooth muscle Myosin heavy chain 11 (MYH11) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunohistochemistry on frozen sections.
  Western Blot.
  Immunofluorescence.
• Reactivities: Bovine, Mammalian
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Bovine tracheal smooth muscle myosin.
• Specificity: This antibody specifically recognises the heavy chain of myosin II found in vertebrate smooth muscle, a non-striated muscle present in the walls of hollow organs, the vasculature, the respiratory and gastrointestinal tracts, uterus, bladder and eye.
  This antibody does not cross-react with myosin of skeletal or non-muscle origin and can be used to specifically stain cultured smooth muscle cells and identify vascular and other smooth muscle types in tissue sections.
• Formulation: 20mM TRIS buffered saline pH7.5, 150mM Nacl. containing 0.006% Sodium Azide (NaN3)
  State: Purified
  State: Purified IgG - liquid
• Storage: Store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens myosin heavy chain 11 (MYH11), transcript variant SM1A
• Database Link:
  Entrez Gene 4629 Human
• Background: The structure of myosin II is fundamentally the same in all muscle types and consists of two heavy chains, each bound by 2 distinct, essential and regulatory light chains. The globular motor domain located at the N-terminal domain of the heavy chains, catalyzes ATP hydrolysis and interacts with actin, whilst the heptad repeat sequences of the heavy chain tail domains promote dimerization, forming an alpha-helical coiled coil at the C-terminal domain.
• Synonyms: SMMHC, MYH11, KIAA0866, Myosin heavy chain 11, smooth muscle

Reference Data

• Protein Pathways: Tight junction, Vascular smooth muscle contraction, Viral myocarditis