IL23 (IL23A) (C-term) Rabbit Polyclonal Antibody

CAT#: AP05588PU-N

IL23 (IL23A) (C-term) rabbit polyclonal antibody, Purified


USD 515.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution Western blot: 1-2 µg/ml. Detects a band of approximately 24kDa in Raji cell lysates.
Immunocytochemistry. 
Immunohistochemistry on Frozen Sections: 10 µg/ml.
Positive control tissue: Raji cells.
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A 14 amino acid peptide from near the carboxy-terminus of human IL-23
Specificity This antibody detects an epitope within the C-terminal (CT) domain of Human Interleukin-23 (IL-23).
Formulation Phosphate buffered saline (PBS)
State: Purified
State: Liquid purified IgG fractioon
Preservative: 0.02% Sodium Azide
Concentration 1.0 mg/ml
Purification Affinity chromatography
Gene Name Homo sapiens interleukin 23 subunit alpha (IL23A)
Background IL23 is a 21kD heterodimeric cytokine structurally related to IL-12. IL-23 is composed of a p19 subunit encoded by the IL23A gene, and a p40 subunit of interleukin-12 (IL12B). IL-23 is expressed mainly by activated macrophages and dendritic cells, and plays an important role in bridging innate and adaptive responses.
IL-23 activates a subset of T cells called Th17 cells, which are characterised by the production of interleukin-17. The IL-23/IL-17 pathway is essential for the induction and maintenance of brain and joint inflammatory autoimmune diseases, including Guillain Barre Syndrome, Multiple sclerosis and rheumatoid arthritis.
Synonyms IL-23 subunit alpha, SGRF, Interleukin-23 subunit p19, IL-23p19
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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