HRK Rabbit Polyclonal Antibody

CAT#: AP05593PU-S

HRK rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of mouse pancreas lysate probed with Rabbit anti Human Hrk (AP05593PU-N) at 2.5 (A) and 5 (B) ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 2 - 5 µg/ml; detects a band of approximately 13kDa in mouse pancreas tissue lysate.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: 15 amino acid peptide from near the centre of human HRK (NP_003797).
• Specificity: This antibody detects Harakiri (HRK), also known as DP5.
• Formulation: State: Purified
  State: Liquid purified IgG containing 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Gene Name: Homo sapiens harakiri, BCL2 interacting protein (HRK), transcript variant 1
• Database Link:
  Entrez Gene 12123 MouseEntrez Gene 117271 RatEntrez Gene 8739 Human
• Background: HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation.
  Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD.
• Synonyms: Neuronal death protein DP5, BID3

Reference Data

• Protein Families: Druggable Genome, Transmembrane