SLUG (SNAI2) Rabbit Polyclonal Antibody

CAT#: AP05600PU-N

SLUG (SNAI2) rabbit polyclonal antibody, Purified


USD 435.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommended Dilution Western blot: 0.5-2.0 µg/ml. Detects a band of approximately 30kDa in 293 cell lysate.
Immunocytochemistry/Immunofluorescence.
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen 13 amino acid peptide sequence near the centre of Human Slug
Specificity This antibody detects Slug, a member of the Snail family of zinc finger transcription factors, whose expression is induced by FGF, BMP, and TGF-beta. This antibody is not cross-reactive with Snail.
Formulation PBS
State: Purified
State: Liquid purified IgG fraction
Preservative: 0.02% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens snail family zinc finger 2 (SNAI2)
Background Slug is a 29kD transcriptional repressor, which functions by binding to E-box motifs and inhibiting gene expression by recruiting histone deacetylase-1 (HDAC-1).
Slug controls the expression of a wide variety of genes including TP53, BRCA2, PUM and CDH1, and has important roles in apoptosis and epithelial-mesenchymal transition. It is also thought to function in neural crest development. Slug expression in breast, oesophageal, and colorectal carcinomas has been correlated with poor prognosis for survival.
Synonyms SLUGH
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Adherens junction

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.