DLL4 Rabbit Polyclonal Antibody

CAT#: AP05661PU-N

DLL4 rabbit polyclonal antibody, Purified


USD 425.00

5 Days*

Size
    • 50 ug

Product Images

Other products for "DLL4"

Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution Immunohistochemistry on paraffin sections: 5 - 15µg/ml.
ELISA: 1:3000 - 1:15000.
Western Blot: 1:300 - 1:1500; detects a band of approximately 74kDa in pancreatic cell lysates.
Reactivities Human, Monkey, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to the internal region of human DLL4.
Specificity This antibody detects human Delta-like ligand 4 (DLL4), also known as Delta-4.
Formulation Phosphate buffered saline pH7.2 containing 0.09% Sodium Azide (NaN3)
State: Purified
State: Liquid purified IgG
Concentration 1.0mg/ml
Gene Name Homo sapiens delta-like 4 (Drosophila) (DLL4)
Background DLL4 is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the Notch receptor Notch1.
DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network.
DLL4 has been found to be strongly expressed in tumour vessels of clear-cell renal tumours and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumour growth, with no apparent toxicity.
Synonyms Delta 4, Drosophila Delta homolog 4
Reference Data
Protein Families Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane
Protein Pathways Notch signaling pathway

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.