HSP90AA1 / HSP90 alpha Rabbit Polyclonal Antibody

CAT#: AP05686PU-N

HSP90AA1 / HSP90 alpha rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: ELISA: 1:5000 - 1:25000.
  Western Blot: 1:500 - 1:2500; detects a band of approximately 90kDa.
• Reactivities: Chicken, Drosophila, Human, Monkey, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to amino acids 289-300 of human heat shock protein 90 alpha.
• Specificity: This antibody detects heat shock protein 90 alpha (HSP90a).
• Formulation: Phosphate buffered saline pH7.2 containing 0.09% Sodium Azide (NaN3)
  State: Purified
  State: Liquid purified IgG
• Concentration: 1.0mg/ml
• Background: HSP90a is one of two HSP90 isoforms together with HSP90b. These isoforms are encoded by different genes and under normal conditions assist the folding of newly synthesised proteins, and are also important in cellular processes such as hormone signalling and cell cycle control. In response to mutation or environmental stress, HSP90 expression is upregulated as part of the heat shock response, and function to maintain newly destabilised proteins in a folding competent state. HSP90 can also affect the epigenetic state at specific loci, leading to phenotype modulation. Induction of HSP90a by c-Myc may control the activity of multiple signal pathways involved in cellular transformation.
• Synonyms: HSP90A, HSPC1, HSPCA, Heat shock 86 kDa, HSP86, NY-REN-38, Heat shock protein HSP 90-alpha