Tgoln2 (Extracell. Dom) Rabbit Polyclonal Antibody

CAT#: AP05793SU-N

Tgoln2 (Extracell. Dom) rabbit polyclonal antibody, Serum

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/100 (Fixation with 3% paraformaldehyde or methanol is recommended).
• Reactivities: Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant fusion protein corresponding to extracellular domain of TGN38.
• Specificity: This antibody recognises a glycoprotein designated TGN38 that is found primarily in the Trans-golgi network, and has been found to be an excellent marker for this cellular organelle. TGN38 is likely to have a role in intracellular transport. It is the homologue of Human TGN46.
• Formulation: State: Serum
  State: Liquid Serum
  Stabilizer: 1% BSA
  Preservative: 0.09% Sodium Azide
• Gene Name: Rattus norvegicus trans-golgi network protein 2 (Tgoln2)
• Database Link:
  Entrez Gene 22135 MouseEntrez Gene 192152 Rat
• Background: The trans-Golgi network (TGN) is part of the secretory pathway of eukaryotic cells which is distinct from the Golgi stack. The TGN is important in the later stages of protein secretion where it seems to play a key role in the sorting and targeting of secreted proteins to the correct destination. Some surface receptors recycle between the cell surface and the TGN, suggesting that the TGN is also important in endocytic pathways. TGN46 cycles between the trans-Golgi network and the cell surface returning via endosomes. It is thought to be involved in regulating membrane traffic to and from trans-Golgi network. Three splice isoforms are found: TGN46, TGN48 and TGN51. Isoform TGN46 is widely expressed, isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells whilst isoform TGN51 is more abundant in fetal lung and kidney. TGN46 is a human specific protein. The rodent homologue of TGN46 is known as TGN38.
• Synonyms: Ttgn1, Golgi Marker, FocusOn119 (Tgoln2, Tgoln1)