ADAM10 Rabbit Polyclonal Antibody

CAT#: AP05830PU-N

ADAM10 rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of Jurkat whole cell lysate probed with Rabbit anti Human CD156c also known as ADAM10

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  Immunocytochemical staining of K562 cells with Rabbit anti Human CD156c

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  Higher magnification of immunocytochemical staining of K562 cells with Rabbit anti Human CD156c

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western blot: 1/1000.
  Immunocytochemistry.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide corresponding to amino acids 732-748 of Human CDw156C.
• Specificity: This antibody recognizes the C-terminal region of the meltalloprotease-disintegrin ADAM-10, also known as CDw156C.
• Formulation: PBS
  State: Purified
  State: Liquid purified IgG fraction
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 102 Human
• Background: ADAM-10 is a member of the mammalian ADAM family and is involved in the cleavage of TNF alpha, Notch and its ligand delta. ADAM-10 mRNA is expressed in a variety of human tissues. Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM-10, CDw156, Mammalian disintegrin-metalloprotease, CD156c or Kuzbanian protein homolog. CD156c is a 748 amino acid ~85 kDa type I, single pass transmembrane glycoprotein with a 19 aa signal peptide and adjacent 194 aa propeptide region yeilding a mature 535 aa protease. CD156c is a member of the mammalian ADAM family and is involved in the cleavage of TNF alpha, Notch and its ligand delta (Primakoff & Miles 2000)
• Synonyms: KUZ, MADM, Kuzbanian protein homolog