DP1 (TFDP1) Rabbit Polyclonal Antibody

CAT#: AP06089PU-N

DP1 (TFDP1) rabbit polyclonal antibody, Aff - Purified


USD 370.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommended Dilution

Western blot: 1/500-1/1000.
Immunohistochemistry on Paraffin sections: 1/50-1/200.
Immunofluorescence: 1/50-1/200.

Reactivities Human
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of DP-1/TFDP1 protein (region surrounding Val393).
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.05% Sodium azide
Concentration 1.0 mg/ml
Purification Affinity chromatography using epitope-specific immunogen (> 95% pure by SDS-PAGE)
Storage

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Predicted Protein Size ~55 kDa
Gene Name Homo sapiens transcription factor Dp-1 (TFDP1), transcript variant 1
Background The human retinoblastoma gene product appears to play an important role in the negative egulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle.
E2F-1 forms heterodimers with a second protein, designated DP-1, forming an “active” E2F transcriptional regulatory complex.
Synonyms Transcription factor Dp-1, DP1, DRTF1
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Cell cycle, TGF-beta signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.