Metabotropic Glutamate Receptor 7 (GRM7) Rabbit Polyclonal Antibody

CAT#: AP06142PU-N

Metabotropic Glutamate Receptor 7 (GRM7) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of mGluR7 antibody in extracts from HuvEc cells.

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  Immunohistochemistry (IHC) analyzes of mGluR7 antibody in Paraffin-Embedded Human brain tissue.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunofluorescence: 1/50 - 1/200.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 860-918 of Human mGluR-7.
• Specificity: This antibody detects endogenous levels of mGluR7 protein.
  (region surrounding Glu894)
• Formulation: PBS, pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 100 kDa
• Gene Name: Homo sapiens glutamate receptor, metabotropic 7 (GRM7), transcript variant 1
• Database Link:
  Entrez Gene 81672 RatEntrez Gene 108073 MouseEntrez Gene 2917 Human
• Background: The mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-7, which can interact with PRKCABP, acts as a receptor for glutamate. It is highly expressed in various areas of the brain, but highest levels are detected in cerebellum, cerebral cortex and hippocampus.
• Synonyms: Metabotropic glutamate receptor 7, GPRC1G, MGLUR7

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction