Integrin beta 5 (ITGB5) Rabbit Polyclonal Antibody

CAT#: AP06183PU-N

Integrin beta 5 (ITGB5) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Integrin β5 antibody at 1/500 dilution Lane 1:Hela whole cell lysate Lane 2:HEK293T whole cell lysate Lane 3:Raw264.7 whole cell lysate Lane 4:Rat kidney tissue lysate

Specifications

Product Data

• Applications: ELISA, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 720-770 of Human Integrin β5.
• Specificity: This antibody antibody detects endogenous levels of Integrin beta5 protein.
  (region surrounding Val746)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 88 kDa
• Gene Name: Homo sapiens integrin subunit beta 5 (ITGB5)
• Database Link:
  Entrez Gene 16419 MouseEntrez Gene 257645 RatEntrez Gene 3693 Human
• Background: Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits. The 16alpha and 8beta subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses. In addition to mediating cell adhesion and cytoskeletal organization, Integrins function as signaling receptors. Signals transduced by Integrins play a role in many 、biological processes, including cell growth, differentiation, migration and apoptosis.
• Synonyms: ITGB-5

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton