alpha Synuclein (SNCA) (pan) Rabbit Polyclonal Antibody

CAT#: AP06338PU-N

alpha Synuclein (SNCA) (pan) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Synuclein-pan antibody in extracts from LOVO cells.

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  Immunohistochemistry (IHC) analyzes of Synuclein-pan antibody in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on paraffin sections: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of 19-30 Synuclein-α.
• Specificity: This antibody detects endogenous levels of Synuclein-pan protein.
  (region surrounding Ala19)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 18 kDa
• Gene Name: Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1
• Database Link:
  Entrez Gene 20617 MouseEntrez Gene 29219 RatEntrez Gene 6622 Human
• Background: Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.
• Synonyms: alpha-synuclein; MGC110988; NACP; OTTHUMP00000161559; OTTHUMP00000161561; PARK1; PARK4; PD1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Parkinson's disease