NM23A (NME1) Rabbit Polyclonal Antibody

CAT#: AP06403PU-N

NM23A (NME1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of NM23/NDP Kinase B antibody in extracts from K562 cells.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 87-130 of Human NM23-H2.
• Specificity: This antibody detects endogenous levels of NM23/NDP Kinase B protein.
  (region surrounding His118)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 23 kDa
• Gene Name: Homo sapiens NME/NM23 nucleoside diphosphate kinase 1 (NME1), transcript variant 2
• Database Link:
  Entrez Gene 18102 MouseEntrez Gene 191575 RatEntrez Gene 4830 Human
• Background: The nm23 protein is the collective designation for two closely related proteins encoded by the genes nm23H1 and nm23H2 now called NME1 and NME2. The protein is expressed in the nucleus and cytoplasm of all normal cells, and on the cell surface of many haematopoietic cells, including erythrocytes. Tumour cells with a high metastatic potential often lack or express only a low amount of nm23 protein, hence the nm23 protein has been described as a metastasis suppressor protein. Recent studies, however, suggest a more complex relationship between occurrence of the nm23 protein and metastatic activity.
• Synonyms: NM23

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Metabolic pathways, Purine metabolism, Pyrimidine metabolism