WNT1 Rabbit Polyclonal Antibody

CAT#: AP06617PU-N

WNT1 rabbit polyclonal antibody, Aff - Purified


USD 407.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution Western blot: 1/500-1/1000.
Immunofluorescence: 1/50-1/200.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Reactivities Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 301-350 of Human Wnt-1.
Specificity This antibody antibody detects endogenous levels of WNT1 protein.
(region surrounding Gly331)
Formulation Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Preservative: 15mM Sodium Azide
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Predicted Protein Size ~ 41 kDa
Background Products of the highly conserved Wnt gene family play key roles in regulating cellular growth and differentiation. The prototype member of the Wnt gene family, Wnt-1, is a cysteine-rich secreted glycoprotein that associates with cell membranes and likely functions as a key regulator of cellular adhesion. β-catenin, a cadherin-binding cellular adhesion protein which also binds the tumor supressor gene APC, has been identified as a downstream target of a signal transduction pathway mediated by Wnt-1. Wnt-1 is essential for normal development of the embryonic nervous system and its expression is normally limited to the embryonic neural tube and adult spermatids. When improperly expressed in mammary tissue, Wnt-1 contributes to hyperplasia and tumorigenic progression. Wnt family members have been shown to interact with Sonic hedgehog (Shh) in vivo to induce myogenesis in somitic tissue.
Synonyms Proto-oncogene protein Wnt-1, INT1, INT-1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.