CDKL2 Rabbit Polyclonal Antibody

CAT#: AP06747PU-N

CDKL2 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of KKIAMRE antibody in extracts from Jurkat cells.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 210-260 of Human KKIAMRE.
• Specificity: This antibody detects endogenous levels of KKIAMRE protein.
  (region surrounding Leu240)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen.
• Predicted Protein Size: ~ 56 kDa
• Gene Name: Homo sapiens cyclin dependent kinase like 2 (CDKL2)
• Database Link:
  Entrez Gene 8999 Human
• Background: The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.
• Synonyms: KKIAMRE

Reference Data

• Protein Families: Druggable Genome, Protein Kinase