ARFBP1 (HUWE1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP07305PU-N

ARFBP1 (HUWE1) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE)

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  Heart: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a 19 amino acid peptide from near the carboxy terminus of ARF-BP1.
• Specificity: This antibody is specific to HUWE1/ARFBP1.
• Formulation: PBS containing 0.09% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified IgG fraction
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Database Link:
  Entrez Gene 10075 Human
• Background: ARFBP1 is a novel E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Also ubiquitinates the p53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.
• Synonyms: URE-binding protein 1, URE-B1, Mule, ARF-BP1, LASU1, HectH9, KIAA0312, KIAA1578, HSPC272