XBP1 Rabbit Polyclonal Antibody

CAT#: AP07389PU-N

XBP1 rabbit polyclonal antibody, Aff - Purified

Product Images

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE)

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  Spleen: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunocytochemistry.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1 - 2 µg/ml.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a 17 amino acid peptide from near the Carboxy terminus of XBP-1.
• Specificity: This antibody reacts to a 17 amino acid peptide from near the carboxy terminus of XBP-1.
• Formulation: Phosphate buffered saline, containing 0.02% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography.
• Storage: Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 7494 Human
• Background: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This gene product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter.
• Synonyms: XBP-1, XBP2