Apc10 (ANAPC10) Rabbit Polyclonal Antibody

CAT#: AP07543PU-N

Apc10 (ANAPC10) rabbit polyclonal antibody, Aff - Purified

Product Images

Pancreas: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide
• Specificity: This antibody reacts to the aa 10-20 of APC10 (Anaphase-promoting complex or cyclosome).
• Formulation: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide
  State: Aff - Purified
  State: Liquid purified Ig
• Concentration: 1 mg/ml
• Purification: Immunoaffinity Chromatography
• Gene Name: anaphase promoting complex subunit 10
• Database Link:
  Entrez Gene 10393 Human
• Background: APC is a ubiquitin ligase which specifically targets mitotic regulatory factors such as Pds 1/Cut 2 and cyclin B. It was found that APC 10/Doc 1 is localized in centrosomes and mitotic spindles throughout mitosis, while it is also localized in kinetochores from prophase to anaphase and in mid body in telophase and cytokinesis. These results strongly support the notion that human APC 10/Doc 1 may be one of the APC core subunits rather than the transiently associated regulatory factor.
• Synonyms: Anaphase-promoting complex subunit 10