Livin (BIRC7) (264-298) Rabbit Polyclonal Antibody

CAT#: AP07670PU-N

Livin (BIRC7) (264-298) rabbit polyclonal antibody, Aff - Purified

Product Images

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, cerebellum.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 2 - 4 µg/ml.
• Reactivities: Human, Monkey
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to Amino Acids 264-280 of the Short form and 281-298 of the Long form of human Livin (1,3)
• Specificity: This antibody detects Livin (1,3).
• Formulation: Phosphate Buffered Saline PBS, containing 0.02% Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified IgG fraction
• Purification: Immunoaffinity Chromatography
• Database Link:
  Entrez Gene 79444 Human
• Background: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP. Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-a and Livin-b. Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
• Synonyms: KIAP, MLIAP, RNF50