LRP6 (Internal) Goat Polyclonal Antibody

CAT#: AP07703PU-N

LRP6 (Internal) goat polyclonal antibody, Aff - Purified

Product Images

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Hepatocytes and Bile Duct.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/64000.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
• Reactivities: Canine, Equine, Hamster, Human, Monkey, Porcine, Rabbit, Rat
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human LRP6 (NP_002327.2)
• Specificity: This antibody recognizes an epitope corresponding to amino acis 1546-1560 of Human LRP6.
• Formulation: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: LDL receptor related protein 6
• Database Link:
  Entrez Gene 4040 Human
• Background: Essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
  Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2).
  Subcellular location: Membrane and Single-pass type I membrane protein.
• Synonyms: LRP-6