Nestin (NES) (1484-1500) Rabbit Polyclonal Antibody

CAT#: AP07829PU-N

Nestin (NES) (1484-1500) rabbit polyclonal antibody, Aff - Purified


USD 475.00

2 Weeks*

Size
    • 50 ug

Product Images

Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommended Dilution ELISA: 1/20000 - 1/80000.
Immunofluorescence.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot: 1/500 - 1/3000.
Reactivities Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein corresponding to amino acids 1484-1500 of Human Nestin
Specificity This antibody recognizes Nestin.
Formulation 0.02M Potassium Phosphate, 0.15M Sodium Chloride, pH 7.2
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.01% (w/v) Sodium Azide
Concentration 1 mg/ml
Purification Immunoaffinity Chromatography
Background Nestin, is a large intermediate filament protein (class Type VI) that was first identified with a monoclonal antibody by Hockfield and McKay (1985). Nestin is expressed predominantly in stem cells of the central nervous system in the neural tube. Nestin is expressed during development and in myotendinous and neuromuscular junctions. Nestin expression is restricted, typically disappearing by E18. Nestin is thought to be a reasonable neuronal marker; however, recent studies have found nestin expression in other cell types such as endothelial cells. Nestin expression is seen in almost all GBMs (Glioblastoma mulitformes) and many melanomas (both primary and metastatic) but not in any metastatic carcinomas. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments.
Synonyms NES, Nbla00170
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.