FOXO3 (600-673) Rabbit Polyclonal Antibody

CAT#: AP08296PU-N

FOXO3 (600-673) rabbit polyclonal antibody, Aff - Purified

Product Images

FOXO3 antibody staining of Formalin-Fixed Paraffin Embedded Human Skin at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 2 - 4 µg/ml.
• Reactivities: Bovine, Canine, Chicken, Human, Monkey, Mouse, Rat, Xenopus
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a portion of the amino acids 600-673 of human FOXO3A.
• Specificity: This antibody recognizes Forkhead Box O3 (FOXO3)
• Formulation: PBS containing 0.05% Sodium Azide as preservative and 0.05% BSA as stabilizer.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography.
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 2309 Human
• Background: FOXO3A belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Forkhead transcription factors of the FoxO subfamily are emerging as a shared component among pathways regulating diverse cellular functions, such as differentiation, metabolism, proliferation, and survival. Their transcriptional output is controlled via a two-tiered mechanism of phosphorylation and acetylation.
  FOXO3A is a transcriptional activator which triggers apoptosis in the absence of survival factors. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO3a has been shown to induce cell growth arrest to effect tumor suppression and FOXO3A genotype is strongly associated with human longevity.
• Synonyms: FOXO3A, AF6q21 protein
• Note: Predicted Molecular Weight: 71 kDa.