HTRA3 (250-300) Rabbit Polyclonal Antibody

CAT#: AP08450PU-N

HTRA3 (250-300) rabbit polyclonal antibody, Purified

Product Images

Liver: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1 - 3 µg/ml.
• Reactivities: Human, Monkey, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: HTRA3 antibody was raised against amino acids 273-287 (IVSTAQREGRELGLR) of Human HtrA3 were used as immunogen.
  Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset (100%); Gorilla, Bovine, Pig, Pufferfish (93%); Mouse, Rat, Panda, Dog, Horse, Turkey, Chicken, Xenopus, Stickleback (87%); Hamster, Elephant, Opossum, Guinea pig, Platypus, Lizard, Salmon, Zebrafish (80%).
• Specificity: This antibody recognizes Serine Protease HTRA3 at aa250-300.
• Formulation: PBS containing 0.2% Gelatin as stabilizer and 0.05% Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Protein G Chromatography
• Database Link:
  Entrez Gene 94031 Human
• Background: HTRA3 belongs to the human high-temperature requirement factor A (HtrA) family. It is also called pregnancy-related serine protease. HtrA3 has two isoforms (long and short), which is produced by alternative splicing. Similar to HTRA1, HTRA3 binds to various TGF-beta proteins and inhibited the signaling of BMP-4, -2 and TGF-beta 1. HtrA3 does not inhibit signaling originated from a constitutively active BMP receptor, indicating that the inhibition occurred upstream of the cell surface receptor.
• Synonyms: PRSP