NRIP (DCAF6) (800-850) Rabbit Polyclonal Antibody

CAT#: AP08452PU-N

NRIP (DCAF6) (800-850) rabbit polyclonal antibody, Aff - Purified

Product Images

Skeletal muscle: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1 - 3 µg/ml.
• Reactivities: Canine, Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a portion of amino acids 800-850 of Human NRIP.
• Specificity: This antibody recognizes IQ Motif And WD Repeats 1 (IQWD1/NRIP).
• Formulation: PBS containing 0.05% BSA and 0.05% Sodium Azide
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: 0.5 mg/ml
• Purification: Immunoaffinity Chromatography.
• Database Link:
  Entrez Gene 55827 Human
• Background: WD-repeat proteins are a large family of eukaryotic proteins coordinating multi-protein complex assemblies and their role has been implicated in multiple cellular processes including signal transduction, transcriptional regulation, cell cycle control and apoptosis. NRIP is a novel 860a.a nuclear protein consisting of seven conserved WD40 domains and one NLS motif. It binds to androgen and glucocorticoid receptors and up regulates their transcriptional activity, thereby functioning as a nuclear receptor coactivator. Role of NRIP has been implicated in cell growth and also in cervical and prostrate cancer thus indicating a therapeutic intervention. Northern Blot analysis detected a high expression of NRIP in skeletal muscle and testis and low expression in heart, prostrate and adrenal gland.
• Synonyms: IQWD1,ARCAP