Fractin (C-term) Rabbit Polyclonal Antibody

CAT#: AP08647SU-N

Fractin (C-term) rabbit polyclonal antibody, Serum

Product Images

Figure 1. Western blot of colchicine treated Sy5y cell lysate showing specific Immunolabeling of the ~32k cleaved Actin fragment (Fractin).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1/1000.
  Immunohistochemistry: 1/100.
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide taken from the C terminus of the 32-kDa Actin fragment.
• Specificity: Specific for the ~ 32 kDa Fractin protein in Western blots with no reactivity to intact actin. There is often a ladder of smaller bands in cells or culture or in vivo preparations due to further degradation by other proteases.
  The antibody has been shown to detect the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer's disease. (Ref.1)
• Formulation: State: Serum
  State: Liquid Neat Serum without preservatives.
• Background: Fractin (fragment of Actin) is a Caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. It has recently been reported that Fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009, in press).
• Synonyms: Fragment of Actin