CAMK2A pThr286 Rabbit Polyclonal Antibody

CAT#: AP08911PU-N

CAMK2A pThr286 rabbit polyclonal antibody, Aff - Purified


USD 440.00

2 Weeks*

Size
    • 50 ul

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Immunohistochemistry on Paraffin Sections: 1/200.
Western Blot: 1/1000.
Reactivities Human, Mouse, Rat, Xenopus
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phosphoThr286 found in Rat brain CaM Kinase II.
Specificity This antibody recognizes Calcium/Calmodulin-dependent Protein Kinase Type II (CAMK2).
Specific for the ~50k a-CaM Kinase II and the ~60k R-CaM Kinase II proteins phosphorylated at Thr286. Immunolabeling is blocked by the X-phosphatase treatment.
Formulation 10mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol
State: Aff - Purified
State: Liquid Purified Ig fraction
Purification Immunoaffinity Chromatography
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens calcium/calmodulin dependent protein kinase II alpha (CAMK2A), transcript variant 2
Background CaMKII (Calcium/calmodulin-dependent protein kinase II) is a ubiquitous serine/threonine protein kinase that is abundant in the brain as a major constituent of the postsynaptic density (PSD). The enzyme is an oligomeric protein composed of distinct but related subunits, alpha, beta, gamma, and delta, each encoded by a separate gene. CAMK2A assembles into heterooligomeric complexes with other CAMK2 subunits.
CaMKII is a prominent kinase in the central nervous system that may function in long term potentiation and neurotransmitter release.
Synonyms CAMK2A, CAMK2B, CAMKA, KIAA0968, CaM-kinase II alpha chain, CaM kinase II subunit alpha, CaMK-II subunit alpha, CaM-kinase II beta chain, CaM kinase II subunit beta, CaMK-II subunit beta
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Calcium signaling pathway, ErbB signaling pathway, Glioma, GnRH signaling pathway, Long-term potentiation, Melanogenesis, Neurotrophin signaling pathway, Olfactory transduction, Oocyte meiosis, Wnt signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.