DUT (1-52) Chicken Polyclonal Antibody

CAT#: AP09036AF-N

DUT (1-52) chicken polyclonal antibody, Azide Free

Product Images

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE)

• 

  Pancreas: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Chicken
• Isotype: IgY
• Clonality: Polyclonal
• Immunogen: Recombinant Human DUT
  Epitope: aa 1-52
• Specificity: This antibody recognizes Amino Acids 1-52 of Human DUTP Pyrophosphatase (DUT).
• Formulation: PBS
  State: Azide Free
  State: Liquid purified IgY fraction
  Preservative: None
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 1854 Human
• Background: Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a ubiquitous enzyme that functions in the hydrolysis of dUTP to dUMP and pyrophosphate. Canman and co-workers have demonstrated that, in certain human tumor cell lines, increased levels of dUTPase are responsible for an increase in resistance to the cancer chemotherapeutic agent fluorodeoxyuridine (FUdR), a thymidine synthase inhibitor. Two distinct forms of dUTPase exist in humans. Cellular fractionation experiments suggest that the more abundant, lower mass form of dUTPase (DUT-N) localizes in the nucleus, while the higher mass form (DUT-M) is associated with the mitochondria.
• Synonyms: dUTPase, dUTP pyrophosphatase