DUT (1-52) Chicken Polyclonal Antibody
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot. |
Reactivities | Human |
Host | Chicken |
Isotype | IgY |
Clonality | Polyclonal |
Immunogen | Recombinant Human DUT Epitope: aa 1-52 |
Specificity | This antibody recognizes Amino Acids 1-52 of Human DUTP Pyrophosphatase (DUT). |
Formulation | PBS State: Azide Free State: Liquid purified IgY fraction Preservative: None |
Purification | Immunoaffinity Chromatography |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | Deoxyuridine triphosphate nucleotidohydrolase (dUTPase) is a ubiquitous enzyme that functions in the hydrolysis of dUTP to dUMP and pyrophosphate. Canman and co-workers have demonstrated that, in certain human tumor cell lines, increased levels of dUTPase are responsible for an increase in resistance to the cancer chemotherapeutic agent fluorodeoxyuridine (FUdR), a thymidine synthase inhibitor. Two distinct forms of dUTPase exist in humans. Cellular fractionation experiments suggest that the more abundant, lower mass form of dUTPase (DUT-N) localizes in the nucleus, while the higher mass form (DUT-M) is associated with the mitochondria. |
Synonyms | dUTPase, dUTP pyrophosphatase |
Reference Data |
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