IKK beta (IKBKB) (310-376) Chicken Polyclonal Antibody

CAT#: AP09040AF-N

IKK beta (IKBKB) (310-376) chicken polyclonal antibody, Azide Free

Product Images

Heart: Formalin-Fixed Paraffin-Embedded (FFPE)

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  Thymus: Formalin-Fixed Paraffin-Embedded (FFPE)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
  Western Blot.
• Reactivities: Human, Mouse, Rat
• Host: Chicken
• Isotype: IgY
• Clonality: Polyclonal
• Immunogen: Recombinant Human IKBKB / IKK Beta
  Epitope: aa310-376
• Specificity: This antibody recognizes Amino Acids 310-376 of IKB Kinase Beta (IKKbeta/IKK2) (IKBKB).
• Formulation: PBS
  State: Azide Free
  State: Liquid purified IgY fraction
  Preservative: None
• Purification: Immunoaffinity Chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 3551 Human
• Background: IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
• Synonyms: I-kappa-B-kinase beta, IKK-beta, IKK-B, I-kappa-B kinase 2, IKK2, NFKBIKB