alpha Synuclein (SNCA) pTyr125 Rabbit Polyclonal Antibody

CAT#: AP09463PU-S

alpha Synuclein (SNCA) pTyr125 rabbit polyclonal antibody, Aff - Purified


USD 230.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications IF, WB
Recommended Dilution Western Blot: 1/500-1/1000.
Immunofluorescence: 1/100-1/200.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Peptide Sequence around the phosphorylation site of Tyr125 (E-A-Yp-E-M) derived from Human Alpha-Synuclein
Specificity This antibody detects endogenous levels of Alpha-Synuclein only when phosphorylated at Tyr125.
Formulation PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Immunoaffinity Chromatography using epitope-specific phosphopeptide.
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Gene Name Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1
Background Alpha-Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues.
Synonyms NACP, PARK1
Note Molecular Weight: 18 kDa
Reference Data
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Parkinson's disease

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.