PPP1R14A (Isoform alpha) Rabbit Polyclonal Antibody

CAT#: AP09505PU-S

PPP1R14A (Isoform alpha) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunofluorescence staining of methanol-fixed HeLa cells using CPI17a antibody

Specifications

Product Data

• Applications: IF
• Recommended Dilution: Immunofluorescence: 1/100 - 1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthesized non-phosphopeptide derived from human CPI17α around the phosphorylation site of threonine 38 (R-V-TP-V-K)
• Specificity: CPI17α antibody detects endogenous levels of total CPI17α protein.
• Formulation: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid purified Ig
• Concentration: 1,0 mg/ml
• Purification: Affinity chromatography
• Gene Name: Homo sapiens protein phosphatase 1 regulatory inhibitor subunit 14A (PPP1R14A), transcript variant 1
• Database Link:
  Entrez Gene 68458 MouseEntrez Gene 114004 RatEntrez Gene 94274 Human
• Background: PKC potentiated inhibitor protein-17 is a 17kDa protein. Expressed in smooth muscles and neuronal cells, CP117 is a myosin phosphatase inhibitor protein. Phosphorylation of CP117 at Thr38 enhances its inhibitory effect by 100 fold. Once phosphorylated, CP117 inhibits PP1c and MLCP holoenzyme activity.
• Synonyms: Protein phosphatase 1 regulatory subunit 14A, CPI-17, CPI17, PPP1INL

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Vascular smooth muscle contraction