NMDAR1 (GRIN1) Rabbit Polyclonal Antibody

CAT#: AP09506PU-N

NMDAR1 (GRIN1) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunofluorescence staining of methanol-fixed HeLa cells using NMDAR1 Antibody

Specifications

Product Data

• Applications: IF
• Recommended Dilution: Immunofluorescence: 1/100-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around amino acids 895~899 (R-S-S-K-D)from Human NMDAR1.
• Specificity: This Antibody detects endogenous levels of total NMDAR1 protein.
• Formulation: PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography using epitope-specific peptide
• Storage: Store the antibody (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens glutamate ionotropic receptor NMDA type subunit 1 (GRIN1), transcript variant GluN1-4a
• Database Link:
  Entrez Gene 14810 MouseEntrez Gene 24408 RatEntrez Gene 2902 Human
• Background: NMDA receptor subtypes of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. NMDAR1 plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission and is involved in the cell surface targeting of NMDA receptors.
• Synonyms: NMDAR1,GRIN1

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Huntington's disease, Long-term potentiation, Neuroactive ligand-receptor interaction