MTOR Rabbit Polyclonal Antibody

CAT#: AP09511PU-S

MTOR rabbit polyclonal antibody, Aff - Purified


USD 230.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Applications IHC
Recommended Dilution Immunohistochemistry: 1/50 - 1/100.
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthesized non-phosphopeptide derived from human mTOR around the phosphorylation site of serine 2481 (I-H-SP-F-I).
Specificity mTOR Antibody detects endogenous levels of total mTOR protein.
Formulation Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
State: Aff - Purified
State: Liquid purified Ig
Concentration lot specific
Purification Affinity chromatography
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens mechanistic target of rapamycin (MTOR)
Background mTOR, or FKBP12 rapamycin associated protein (FRAP), is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.
Synonyms Mammalian target of rapamycin, TOR, FRAP, FRAP2, RAPT1
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Acute myeloid leukemia, Adipocytokine signaling pathway, ErbB signaling pathway, Glioma, Insulin signaling pathway, mTOR signaling pathway, Pathways in cancer, Prostate cancer, Type II diabetes mellitus

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.