CBL Rabbit Polyclonal Antibody

CAT#: AP09517PU-N

CBL rabbit polyclonal antibody, Aff - Purified


USD 300.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Applications IHC
Recommended Dilution Immunohistochemistry: 1/50 - 1/100.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthesized non-phosphopeptide derived from human c-Cbl around the phosphorylation site of tyrosine 700 (T-E-YP-M-T)
Specificity c-Cbl Antibody detects endogenous levels of total c-Cbl protein.
Formulation Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
State: Aff - Purified
State: Liquid purified Ig
Concentration lot specific
Purification Affinity chromatography
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL)
Background The proto-oncogene c-CBL was initially identified as the cellular homologue of v-CBL oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap-70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL’s interaction with downstream targets of tyrosine kinases, such as PI-3K and Vav.
Synonyms RING finger protein 55, CBL2, c-CBL
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Chronic myeloid leukemia, Endocytosis, ErbB signaling pathway, Insulin signaling pathway, Jak-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Ubiquitin mediated proteolysis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.