Plakophilin 4 (PKP4) (Peptide 1-1 to 1-4) Guinea Pig Polyclonal Antibody

CAT#: AP09543SU-N

Plakophilin 4 (PKP4) (Peptide 1-1 to 1-4) guinea pig polyclonal antibody, Serum

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western Blot: 1/1000.
  Immunofluorescence: 1/100.
  Immunohistochemistry on frozen and paraffin sections.
  Immunoelectron microscopy.
  Incubation time: 1-1.5 h at RT
• Reactivities: Bovine, Human, Mouse
• Host: Guinea Pig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide cocktail of human p0071: Peptide 1-1 to 1-4 (aa positions: aa 85-104; aa 173-193; aa 359-382; aa 407-430)
• Specificity: Stains an armadillo plaque protein that characterizes a specific subtype of adherens junctions and their functions.
  This plaque protein (p0071) is specific for a subtype of adherens junctions, with a molecular mass of 135 kD. p0071 is specifically detected in the plaques of the composite junctions (area compositae) of cardiac intercalated disks, in puncta adhaerentia of single- and multi-layered epithelia and blood vessel endothelial cells.; it is, however, absent from desmosomes.
  Recommended Positive Control: MCF-7.
  
  Reactivities on cultured cell lines (tested so far):
  MCF-7, MH1C1, 3T3, RVF-SMV.
• Formulation: State: Serum
  State: Liquid stabilized antiserum containing 0.09% sodium azide
• Database Link:
  Entrez Gene 8502 Human
• Background: Plakophilin 4 (PKP4) is an Armadillo-like protein, characterized by a series of armadillo repeats. It is a component of desmosomal plaques and may play a role in junctional plaque organization.
• Synonyms: PKP4, p0071