Plakophilin 1 (PKP1) Guinea Pig Polyclonal Antibody

CAT#: AP09553SU-N

Plakophilin 1 (PKP1) guinea pig polyclonal antibody, Serum

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunofluorescence Microscopy on Frozen Sections: 1/100 (After paraformaldehyde fixation).
  Immunobloting (Western Blot): 1/1000.
  Immunohistochemistry on Frozen and Paraffin Sections.
  Incubation Time: 1h at RT, extended with Paraffin Sections.
• Reactivities: Bovine, Human, Mouse, Xenopus
• Host: Guinea Pig
• Clonality: Polyclonal
• Immunogen: Human recombinant Plakophilin 1.
• Specificity: PP1 antiserum shows distinct suprabasal staining of stratified epithelia, localizing Plakophilin 1 in desmosomal plaques and in the nucleus.
  In Western blot analysis the antiserum reacts specifically with the Plakophilin 1a and 1b polypeptides.
• Formulation: State: Serum
  State: Liquid stabilized antierum
  Preservative: 0.09% Sodium Azide
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens plakophilin 1 (PKP1), transcript variant 1b
• Database Link:
  Entrez Gene 5317 Human
• Background: Plays a role in formation of desmosomal plaques and is found in desmosomes of most simple and stratified epithelia. Not found in cell types that have non-epithelial desmosomes. Absent in fibroblasts and other connective tissue types, including sarcomas.
• Synonyms: Plakophilin-1, Band 6 protein, B6P

Reference Data

• Protein Families: Druggable Genome