MAD3 (MXD3) (C-term) Goat Polyclonal Antibody
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Specifications
Product Data | |
Applications | ELISA, IF, IHC |
Recommended Dilution | Peptide ELISA: 1/4000 (Detection Limit). Western blot: No signal obtained yet but low background observed in NCI-H460, HepG2, Human Liver, Human Heart and Human Brain lysates at up to 3 µg/ml. Immunocytochemistry: This product has been successfully used by an anonymous Customer on Methanol-fixed and 0.5% TX100-permeabilized HeLa cells, staning the cytoplasm. Immunohistochemistry: An anonymous Customer found positive results on Human HeLa cells. |
Reactivities | Human |
Host | Goat |
Clonality | Polyclonal |
Immunogen | Synthetic peptide from the C-Terminus of Human MAD3 (NP_112590.1) |
Specificity | This antibody is expected to recognise isoform a (NP_112590.1) only. |
Formulation | Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified Ig fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide |
Concentration | 0.5 mg/ml |
Purification | Immunoaffinity Chromatography |
Gene Name | Homo sapiens MAX dimerization protein 3 (MXD3), transcript variant 2 |
Database Link | |
Background | MAD3 contains 1 basic helix-loop-helix (bHLH) domain. It is a transcriptional repressor and binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. |
Synonyms | MAD-3, MXD3,Max-interacting transcriptional repressor MAD3 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
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