GABA A Receptor beta 3 (GABRB3) Goat Polyclonal Antibody

CAT#: AP10064PU-N

GABA A Receptor beta 3 (GABRB3) goat polyclonal antibody, Aff - Purified

Product Images

Anti-GABRB3 (2.5ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: Peptide ELISA: 1/8000.
  Immunohistochemistry on paraffin sections: Human Cortex shows patchy staining near or at the neuronal cell membrane.
  Recommended concentration: 2-4µg/ml.
• Reactivities: Bovine, Canine, Human, Mouse, Rat
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-EKTAKAKNDRSK, from the internal region of the protein sequence according to NP_000805.1; NP_068712.1.
• Specificity: This antibody reacts to GABRB3.
• Formulation: Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens gamma-aminobutyric acid type A receptor beta3 subunit (GABRB3), transcript variant 1
• Database Link:
  Entrez Gene 14402 MouseEntrez Gene 24922 RatEntrez Gene 2562 Human
• Background: GABA A Receptor beta 3 is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system.
  The GABAA receptor complex is the molecular target of the benzodiazepine class of tranquilizer drugs, and hence it is also often referred to as the 'benzodiazepine receptor'. The GABAA receptor complex also appears to have distinct binding sites for a variety of other pharmaco-active compounds.
• Synonyms: GABRB-3, GABA A receptor subunit beta-3

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction