Bcl2 Binding component 3 (BBC3) (BH3 Domain) Rabbit Polyclonal Antibody
CAT#: AP11313PU-N
Bcl2 Binding component 3 (BBC3) (BH3 Domain) rabbit polyclonal antibody, Purified
Specifications
Product Data | |
Applications | FC, IF, IHC, WB |
Recommended Dilution | ELISA: 1/1,000. Western blot: 1/100-1/500. Flow Cytometry: 1/10-1/50. Immunofluorescence: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/50-1/100. |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | Synthetic peptide selected from the C-terminal region of Human PUMA |
Specificity | This antibody is specific to Human and Mouse PUMA (BH3 Domain). Other species not tested. |
Formulation | PBS containing 0.09% (W/V) Sodium Azide as preservative State: Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | 20532 Da |
Gene Name | BCL2 binding component 3 |
Database Link | |
Background | PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
Synonyms | BBC3, JFY-1 |
Reference Data |
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