FDPS Rabbit Polyclonal Antibody

CAT#: AP12197PU-N

FDPS rabbit polyclonal antibody, Purified

Product Images

The anti-FDPS Pab is used in Western blot to detect FDPS in human cytokeratin liver cell lysate. Data is kindly provided by Dr. Masaru Harada from Stanford University (Palo Alto, CA).

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  Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with FDPS antibody (Center ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blot: 1/100-1/500.
  Immunohistochemistry: 1/50-1/100.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human FDPS.
• Specificity: This antibody detects FDPS (Center).
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: farnesyl diphosphate synthase
• Database Link:
  Entrez Gene 2224 Human
  UniProt ID P14324
• Background: The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
• Synonyms: Farnesyl pyrophosphate synthetase, FPS, FDPS, KIAA1293, Farnesyl diphosphate synthase
• Note: Molecular weight: 40532 Da