RIP2 (RIPK2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP14642PU-N

RIP2 (RIPK2) (C-term) rabbit polyclonal antibody, Purified

Product Images

(LEFT) Western blot analysis of anti-RIPK2 Pab in Ramos cell line lysates (35ug/lane). RIPK2 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of anti-RIPK2 Pab in mouse cerebellum tissue lysate. RIPK2 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

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  (LEFT)Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (RIGHT)Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with RIPK2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blotting: 1/1000.
  Immunohistochemistry: 1/50 - 1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between aa 458 - 488 from the C-terminal region of human RIPK2.
• Specificity: This antibody reacts to RIP2 (RIIPK2).
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens receptor interacting serine/threonine kinase 2 (RIPK2)
• Database Link:
  Entrez Gene 192656 MouseEntrez Gene 8767 Human
• Background: RIPK2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
• Synonyms: CARDIAK, RICK, RIP2, RIP-2, Receptor-interacting protein 2

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Neurotrophin signaling pathway, NOD-like receptor signaling pathway