TGF beta Receptor I (TGFBR1) (Center) Rabbit Polyclonal Antibody

CAT#: AP14647PU-N

TGF beta Receptor I (TGFBR1) (Center) rabbit polyclonal antibody, Purified

Product Images

(LEFT) Western blot analysis of anti-TGFBR1 Pab in Jurkat cell line lysates (35ug/lane). TGFBR1 (arrow) was detected using the purified Pab. (RIGHT) The anti-TGFBR1 Pab is used in Western blot to detect TGFBR1 in mouse small intestine tissue lysate.

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  Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100 - 1/500.
  Immunohistochemistry: 1/50 - 1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human TGFBR1.
• Specificity: This antibody reacts to TGF beta Receptor I (TGFBR1).
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: transforming growth factor beta receptor 1
• Database Link:
  Entrez Gene 7046 Human
  UniProt ID P36897
• Background: The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
• Synonyms: TGF-beta receptor type-1, TGF-beta type I receptor, TbetaR-I, TGFR-1, ALK5, SKR4