ACK1 (TNK2) (N-term) Rabbit Polyclonal Antibody

CAT#: AP17080PU-N

ACK1 (TNK2) (N-term) rabbit polyclonal antibody

Product Images

Western blot analysis of ACK1 (arrow) using rabbit polyclonal ACK1 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACK1 gene (Lane 2) (60 KD recombinant protein).

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1:50 - 1:100.
  ELISA: 1:1,000.
  Immunohistochemistry on frozen sections.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the N-terminal region of human ACK1
• Specificity: This antibody detects TNK2 / ACK1 at N-term.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
• Storage: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens tyrosine kinase non receptor 2 (TNK2), transcript variant 2
• Database Link:
  Entrez Gene 10188 Human
• Background: ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
• Synonyms: ACK; ACK-1; ACK1; FLJ44758; FLJ45547; p21cdc42Hs
• Note: Molecular weight: 114327 Da

Reference Data

• Protein Families: Druggable Genome, Protein Kinase