CD21 (CR2) (C-term) Rabbit Polyclonal Antibody

CAT#: AP17240PU-N

CD21 (CR2) (C-term) rabbit polyclonal antibody

Product Images

Western blot analysis of CD21 antibody (C-term) in Ramos cell line lysates (35 ug/lane). CR2 (arrow) was detected using the purified Pab.

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  Formalin-fixed and paraffin-embedded human Lymph reacted with CD21 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: Peptide ELISA: 1/1,000.
  Western blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/50-1/100.
  Flow Cytometry: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 986-1014 amino acids from the C-terminal region of Human CR2.
• Specificity: This antibody detects CD21 at C-term.
• Formulation: PBS
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) Sodium Azide
• Concentration: lot specific
• Purification: Purified through a protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 112916 Da
• Gene Name: complement component 3d receptor 2
• Database Link:
  Entrez Gene 1380 Human
  UniProt ID P20023
• Background: CR2 is a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes.
  Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.
  Cellular Location: Membrane; Single-pass type I membrane protein.
  Tissue Location:Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.
• Synonyms: Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic Cell Marker

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: B cell receptor signaling pathway, Complement and coagulation cascades, Hematopoietic cell lineage