IMPDH2 Rabbit Polyclonal Antibody

CAT#: AP17504PU-N

IMPDH2 rabbit polyclonal antibody

Product Images

Western blot analysis of IMPDH2 Antibody (Center) in NCI-H460, Hela, MCF7, A2058 cell line lysates (35ug/lane). IMPDH2 (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Center region of human IMPDH2
• Specificity: This antibody reacts to IMPDH2.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 (IMPDH2)
• Database Link:
  Entrez Gene 3615 Human
• Background: IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Its gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
• Synonyms: IMPD2, Inosine-5'-monophosphate dehydrogenase 2, IMP dehydrogenase 2, EC=1.1.1.205, IMPDH-II, IMPD-2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism