Myeloid leukemia factor 1 (MLF1) (N-term) Rabbit Polyclonal Antibody

CAT#: AP17562PU-N

Myeloid leukemia factor 1 (MLF1) (N-term) rabbit polyclonal antibody

Product Images

Western blot analysis of MLF1 Antibody (N-term) in mouse heart tissue lysates (35ug/lane). MLF1 (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the N-terminal region of human MLF1
• Specificity: This antibody reacts to Myeloid leukemia factor 1.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purfied Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens myeloid leukemia factor 1 (MLF1), transcript variant 1
• Database Link:
  Entrez Gene 17349 MouseEntrez Gene 4291 Human
• Background: MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
• Synonyms: MLF1

Reference Data

• Protein Families: Druggable Genome