VDAC1 (N-term) Rabbit Polyclonal Antibody

CAT#: AP17825PU-N

VDAC1 (N-term) rabbit polyclonal antibody, Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications FC, IHC, WB
Recommended Dilution Peptide ELISA: 1/1,000.
Western blotting: 1/1,000.
Flow cytometry: 1/10-1/50.
Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human VDAC1.
Specificity This antibody recognizes VDAC-1.
Formulation PBS with 0.09% (W/V) Sodium Azide as preservative.
State: Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Purified through a protein A column, followed by peptide affinity purification
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens voltage dependent anion channel 1 (VDAC1), transcript variant 1
Background VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Synonyms VDAC, Porin 31HL, Porin 31HM, Mitochondria marker
Note Calculated MW: 30773 Da
Reference Data
Protein Families Ion Channels: Other
Protein Pathways Calcium signaling pathway, Huntington's disease, Parkinson's disease

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.