Von Hippel Lindau (VHL) (C-term) Rabbit Polyclonal Antibody

CAT#: AP17826PU-N

Von Hippel Lindau (VHL) (C-term) rabbit polyclonal antibody


USD 450.00

2 Weeks*

Size
    • 400 ul

Product Images

Specifications

Product Data
Applications WB
Recommended Dilution ELISA: 1/1,000.
Western blotting: 1/50 - 1/100.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of human VHL
Specificity This antibody reacts to VHL.
Formulation PBS with 0.09% (W/V) sodium azide
State: Liquid purified Ig
Concentration lot specific
Purification Saturated Ammonium Sulfate (SAS) precipitation
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens von Hippel-Lindau tumor suppressor (VHL), transcript variant 1
Background Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of VHL gene is the basis of familial inheritance of VHL syndrome. The protein is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein.
Synonyms Von Hippel-Lindau disease tumor suppressor
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.