alpha 2b Adrenergic Receptor (ADRA2B) Rabbit Polyclonal Antibody

CAT#: AP17872PU-N

alpha 2b Adrenergic Receptor (ADRA2B) rabbit polyclonal antibody, Aff - Purified


USD 450.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications FC, IF, IHC, WB
Recommended Dilution Western blotting: 1/1000.
Flow Cytometry: 1/10-1/50.
Immunofluorescence: 1/10-1/50.
Immunohistochemistry (Paraffin): 1/50-1/100.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 343-369 amino acids from the Center region of Human ADRA2B.
Specificity This antibody recognizes Alpha-2B adrenergic receptor.
Formulation PBS with 0.09% (W/V) Sodium Azide as preservative
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Affinity Chromatography on Protein A followed by peptide affinity purification.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens adrenoceptor alpha 2B (ADRA2B)
Background Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
Synonyms ADRA2L1, ADRA2RL1, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor
Reference Data
Protein Families Druggable Genome
Protein Pathways Neuroactive ligand-receptor interaction

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.