Complement C5 (C5) (N-term) Rabbit Polyclonal Antibody

CAT#: AP17914PU-N

Complement C5 (C5) (N-term) rabbit polyclonal antibody

Product Images

Western blot analysis of C5 Antibody (N-term) in HL-60 cell line lysates (35ug/lane). C5 (arrow) was detected using the purified Pab. (2ug/ml)

Specifications

Product Data

• Applications: FC, IHC, WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/1,000.
  Immunohistochemistry: 1/50-1/100.
  Flow Cytometry: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 253-281 amino acids from the N-terminal region of human C5.
• Specificity: This antibody recognizes Complement C5.
• Formulation: PBS
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement C5 (C5), transcript variant 1
• Database Link:
  Entrez Gene 727 Human
• Background: C5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.
• Synonyms: CPAMD4, Complement component 5

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus