CD146 (MCAM) Rabbit Polyclonal Antibody

CAT#: AP18112PU-N

CD146 (MCAM) rabbit polyclonal antibody

Product Images

Western blot analysis of MCAM Antibody (Center) in A2058 cell line lysates (35ug/lane). MCAM (arrow) was detected using the purified Pab. (2ug/ml)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/50 - 1/100.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the Center region of human MCAM
• Specificity: This antibody reacts to CD146.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Saturated Ammonium Sulfate (SAS) precipitation
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens melanoma cell adhesion molecule (MCAM)
• Database Link:
  Entrez Gene 4162 Human
• Background: MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
• Synonyms: MCAM, MUC18, CD146

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane